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This review discusses the role of RNA-binding proteins from Trypanosoma cruzi and their homologues in regulating gene expression in yeast, highlighting their importance in post-transcriptional processes.
This review highlights the critical role of RNA-binding proteins in post-transcriptional gene expression regulation in Trypanosoma cruzi and Saccharomyces cerevisiae.
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No direct clinical implications for Chagas cardiomyopathy; leaves open research on these proteins as targets.
RNA-binding proteins (RBPs) have important functions in the regulation of gene expression. RBPs play key roles in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport and modulation of mRNA translation and decay. RBPs assemble into different mRNA-protein complexes, which form messenger ribonucleoprotein complexes (mRNPs). Gene expression regulation in trypanosomatids occurs mainly at the post-transcriptional level and RBPs play a key role in all processes. However, the functional characterization of RBPs in Trypanosoma cruzi has been impaired due to the lack of reliable reverse genetic manipulation tools. The comparison of RBPs from Saccharomyces cerevisiae and T. cruzi might allow inferring on the function of these proteins based on the information available for the orthologous RNA-binding proteins from the S. cerevisiae model organism. In this review, we discuss the role of some RBPs from T. cruzi and their homologues in regulating gene expression in yeast.
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Oliveira et al. (2017) conducted a review in Gene expression regulation in Trypanosoma cruzi and Saccharomyces cerevisiae. RNA-binding proteins was evaluated. This review discusses the role of RNA-binding proteins from Trypanosoma cruzi and their homologues in regulating gene expression in yeast, highlighting their importance in post-transcriptional processes.
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