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August 1, 1998Anesthesia & Analgesia

Ketamine Attenuates the Interleukin-6 Response After Cardiopulmonary Bypass

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Why the study?

Does ketamine reduce serum IL-6 levels in patients undergoing elective CABG?

Population

31 patients undergoing elective coronary artery bypass grafting (CABG)

Comparison

Ketamine 0.25 mg/kg added to large-dose fentanyl… vs Isotonic sodium chloride solution added to…

Design

RCT, randomized to one of two groups, double-blind

Follow-up

8 days

Authors

LRLeonid RoytblatBen-Gurion University of the NegevDTDaniel TalmorCross-Cutting CardiologyMRMaxim RachinskyUniversity Health Network

Discussion

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Implication

Ketamine attenuates postoperative inflammation in CABG; extends RCT evidence for its immunomodulatory effects in cardiac surgery.

Structured PICO

Does ketamine reduce serum IL-6 levels in patients undergoing elective CABG?

P
Population
31 patients undergoing elective coronary artery bypass grafting (CABG)
I
Intervention
Ketamine 0.25 mg/kg added to large-dose fentanyl anesthesia before cardiopulmonary bypass
C
Comparator
Isotonic sodium chloride solution (placebo) added to large-dose fentanyl anesthesia
O
Outcome
Serum interleukin-6 (IL-6) levels measured before operation, after CPB, 4, 24, and 48 h after surgery, and daily for 6 dayssurrogate

A single small dose of ketamine added to general anesthesia before cardiopulmonary bypass significantly suppresses the systemic inflammatory response, as measured by serum IL-6 levels, up to 7 days postoperatively.

Cite This Study

Roytblat et al. (1998) studied this question.

synapsesocial.com/papers/6a963c89f69cd3f69201f29dhttps://doi.org/10.1213/00000539-199808000-00006
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Also Consider

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  1. 1Postoperative Pain1993 · 241 citations
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