January 1, 1998Anesthesia & Analgesia

Does the Duration of Cardiopulmonary Bypass or Aortic Cross-Clamp, in the Absence of Blood and/or Blood Product Administration, Influence the IL-6 Response to Cardiac Surgery?

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Why the study?

Does the duration of cardiopulmonary bypass or aortic cross-clamp influence the IL-6 response in patients undergoing cardiac surgery without blood product administration?

Population

16 patients undergoing cardiopulmonary bypass who did not receive blood and/or blood products during the…

Design

Cohort

Follow-up

at sternal closure

Authors

CWCharles W. Whitten GHGary E. Hill RIRoy Ivy

Discussion

Member takes

Overview

May warrant minimizing CPB duration to limit inflammation; leaves open independent effects of aortic cross-clamp time.

Structured PICO

Does the duration of cardiopulmonary bypass or aortic cross-clamp influence the IL-6 response in patients undergoing cardiac surgery without blood product administration?

Population

16 patients undergoing cardiopulmonary bypass (coronary artery bypass grafting, n = 9; valvular cardiac surgery, n = 7) who did not receive blood and/or blood products during the study.

Intervention

Duration of cardiopulmonary bypass (CPB) and aortic cross-clamp time.

Outcome

Absolute increase in plasma IL-6 levels from preinduction (T0) to sternal closure.surrogate

The magnitude of the IL-6 inflammatory response correlates positively with the duration of cardiopulmonary bypass, but not aortic cross-clamp time, independent of blood product transfusion.

Cite This Study

Whitten et al. (1998) studied this question.

synapsesocial.com/papers/6a9fba48fe80d3ecfb7c6727 https://doi.org/10.1213/00000539-199801000-00006

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January 1, 1998Anesthesia & Analgesia

Does the Duration of Cardiopulmonary Bypass or Aortic Cross-Clamp, in the Absence of Blood and/or Blood Product Administration, Influence the IL-6 Response to Cardiac Surgery?

View Full Paper

Ask AI

Bookmark

Why the study?

Does the duration of cardiopulmonary bypass or aortic cross-clamp influence the IL-6 response in patients undergoing cardiac surgery without blood product administration?

Population

16 patients undergoing cardiopulmonary bypass who did not receive blood and/or blood products during the…

Design

Cohort

Follow-up

at sternal closure

Authors

CWCharles W. Whitten GHGary E. Hill RIRoy Ivy

Discussion

Member takes

Overview

May warrant minimizing CPB duration to limit inflammation; leaves open independent effects of aortic cross-clamp time.

Structured PICO

Does the duration of cardiopulmonary bypass or aortic cross-clamp influence the IL-6 response in patients undergoing cardiac surgery without blood product administration?

Population

16 patients undergoing cardiopulmonary bypass (coronary artery bypass grafting, n = 9; valvular cardiac surgery, n = 7) who did not receive blood and/or blood products during the study.

Intervention

Duration of cardiopulmonary bypass (CPB) and aortic cross-clamp time.

Outcome

Absolute increase in plasma IL-6 levels from preinduction (T0) to sternal closure.surrogate

The magnitude of the IL-6 inflammatory response correlates positively with the duration of cardiopulmonary bypass, but not aortic cross-clamp time, independent of blood product transfusion.

Cite This Study

Whitten et al. (1998) studied this question.

synapsesocial.com/papers/6a9fba48fe80d3ecfb7c6727 https://doi.org/10.1213/00000539-199801000-00006

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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