Key result
Genistein directly inhibits Kv4.3 channels in a concentration-dependent manner (IC50 124.78 μM) by interacting with the closed-inactivated state, independent of protein tyrosine kinase activity.
Authors
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No immediate clinical implications for genistein use; leaves open effects on cardiac electrophysiology in vivo.
Kim et al. (2010) studied this question. Genistein vs. Control conditions / other PTK inhibitors was evaluated on Inhibition of Kv4.3 channel. Genistein directly inhibits Kv4.3 channels in a concentration-dependent manner (IC50 124.78 μM) by interacting with the closed-inactivated state, independent of protein tyrosine kinase activity.
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