Why the study?
Does acute intravenous propranolol improve left ventricular diastolic distensibility and filling dynamics in patients with hypertrophic obstructive cardiomyopathy?
Does acute intravenous propranolol improve left ventricular diastolic distensibility and filling dynamics in patients with hypertrophic obstructive cardiomyopathy?
Acute beta-blockade with propranolol does not improve left ventricular distensibility or diastolic filling in patients with hypertrophic obstructive cardiomyopathy, and may actually impede pressure-independent filling.
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Acute propranolol does not support targeting diastolic distensibility in HOCM; leaves open chronic beta-blockade effects on filling.
Speiser et al. (1981) studied this question.
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