Why the study?
Does angiotensin infusion alter renal function and blood pressure in unanesthetized dogs?
Population
Unanesthetized dogs
Comparison
Angiotensin infusion (low and high doses) vs Control values (baseline)
Design
Preclinical
Follow-up
up to >50 minutes
Authors
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Dose-dependent renal effects in dogs warrant caution against human extrapolation; leaves open tubular sodium handling mechanisms for validation.
Does angiotensin infusion alter renal function and blood pressure in unanesthetized dogs?
Angiotensin has dose-dependent effects on renal hemodynamics and electrolyte excretion in dogs, suggesting it can block tubular sodium reabsorption.
Healy et al. (1965) studied this question.
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