Key result
Angiotensin increases sodium excretion by ~215% in dogs treated with reserpine and guanethidine.
Why the study?
Does angiotensin improve sodium excretion in dogs anesthetized with morphine-chloralose?
Population
Dogs anesthetized with morphine-chloralose
Comparison
Angiotensin administered after sympathetic… vs Untreated dogs and dogs treated with reserpine…
Design
Preclinical
Authors
Loading...
Angiotensin may exert direct tubular natriuresis when sympathetic activity is blocked in dogs; leaves open translation to intact physiology or clinical sodium handling.
Does angiotensin improve sodium excretion in dogs anesthetized with morphine-chloralose?
Absolute Event Rate: 189% vs 60%
Angiotensin has a renal tubular action promoting natriuresis that is unmasked by sympathetic blockade with reserpine and guanethidine.
John C. McGiff (1967) studied this question. Angiotensin vs. Control state (untreated) was evaluated on Sodium excretion (natriuresis). In dogs treated with reserpine and guanethidine, angiotensin produced a natriuresis, increasing sodium excretion from 60 to 189 µEq Na/min at a low dose and 75 to 353 µEq Na/min at a high dose.