Key result
Cryoballoon ablation was non-inferior to radiofrequency ablation for the treatment of paroxysmal atrial fibrillation, with single-procedure success rates of 42% and 40% respectively at 30 months (p < 0.001 for non-inferiority).
Why the study?
Does cryoballoon ablation provide non-inferior procedural success compared to radiofrequency ablation in patients with drug-refractory paroxysmal atrial fibrillation?
Population
315 patients with drug-refractory paroxysmal atrial fibrillation
Comparison
Cryoballoon (CB) ablation vs Open irrigated radiofrequency (RF) ablation
Design
RCT, randomised
Follow-up
30 months
Authors
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Supports cryoballoon as alternative to radiofrequency ablation; confirms non-inferior single-procedure success in paroxysmal AF.
RCT (n=315)
Random number generation software
Does cryoballoon ablation provide non-inferior procedural success compared to radiofrequency ablation in patients with drug-refractory paroxysmal atrial fibrillation?
Absolute Event Rate: 42% vs 40%
p-value: p=<0.001 for non-inferiority
Cryoballoon ablation is non-inferior to radiofrequency ablation for long-term (30-month) procedural success in patients with drug-refractory paroxysmal atrial fibrillation.
Luik et al. (2017) conducted an RCT in Paroxysmal atrial fibrillation (n=315). Cryoballoon ablation vs. Open irrigated radiofrequency ablation was evaluated on Procedural success (freedom from AF with an absence of persistent complications) at 30 months (p=<0.001 for non-inferiority). Cryoballoon ablation was non-inferior to radiofrequency ablation for the treatment of paroxysmal atrial fibrillation, with single-procedure success rates of 42% and 40% respectively at 30 months (p < 0.001 for non-inferiority).
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