Key result
Phylogenetic analysis of 40 PCV2 sequences from Shandong Province (2013-2018) revealed the coexistence of genotypes 2a, 2b, and 2d, with PCV2d emerging as the dominant genotype.
Why the study?
PCV2 causes postweaning multisystemic wasting syndrome and has caused serious damage to the pig industry in China since 2000.
Observational (n=40)
Shandong PCV2 sequences reveal ongoing evolution; leaves open optimal surveillance and vaccine updates for swine herds.
PCV2 belongs to the genus Circovirus, family Circoviridae, who is recognized as the causative agents of postweaning multisystemic wasting syndrome. Since being found to China in 2000, it has caused serious damage to the pig industry. In this study, we downloaded 40 PCV2 genome-wide sequences uploaded to GenBank from 2013 to 2018 in Shandong Province, including 23 uploaded by our laboratory. Construction of a genome-wide evolution tree using MEGA V5.0 software. Phylogenetic tree analysis indicated that the genotype of PCV2 in Shandong Province was: three genotypes coexisted (2a, 2b, 2d); among them, PCV2d has become the main genotype in the province due to its number and spread range. Amino acid sequence analysis of different genotypes of ORF2 showed that specific amino acid sites exist in different genotypes, with the most significant range of 81-160; different genotypes of PCV2 can be distinguished at the molecular level. This study found that due to the increase in infections of the PCV2d genotype in recent years, it may replace PCV2b as the dominant base in Shandong.
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Wang et al. (2019) conducted an observational in Porcine circovirus type 2 (PCV2) infection (n=40). PCV2 genotype analysis was evaluated on Genotype distribution and amino acid sequence variations. Phylogenetic analysis of 40 PCV2 sequences from Shandong Province (2013-2018) revealed the coexistence of genotypes 2a, 2b, and 2d, with PCV2d emerging as the dominant genotype.
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