Why the study?
Does varying inspired oxygen and carbon dioxide pressures affect cardiac output in unanesthetized rabbits?
Does varying inspired oxygen and carbon dioxide pressures affect cardiac output in unanesthetized rabbits?
In unanesthetized rabbits, a combination of hypoxia (10% O2) and hypercapnia (5% CO2) significantly reduces cardiac output, whereas high O2 or CO2 alone do not.
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Combined hypoxia-hypercapnia reduces cardiac output in rabbits; leaves open relevance to human cardiorespiratory physiology.
An experiment was carried out on twenty‐four rabbits in which the inspired O2 was either 50 per cent, 21 per cent or 10 per cent and the inspired CO2O per cent or 5 per cent. High arterial pO2 or prolonged respiratory stimulation by CO2 resulted in no significant change in cardiac output, blood pressure or heart rate during the steady state. With 10 per cent O2+5 per cent CO2 there was a significant fall in cardiac output.
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Korner et al. (1960) studied this question.
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