Key result
Following accidental exposure to a wild poliovirus type 2 spill, one of two fully vaccinated operators shed the virus for 29 days, with no further transmission detected.
Case Report (n=2)
No
Prompt isolation and monitoring of a fully vaccinated operator exposed to wild poliovirus type 2 successfully prevented further transmission.
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No secondary transmission after WPV2 exposure in a vaccinated operator; leaves open standardized post-exposure protocols.
On 3 April 2017, a wild poliovirus type 2 (WPV2) spill occurred in a Dutch vaccine manufacturing plant. Two fully vaccinated operators with risk of exposure were advised on stringent personal hygiene and were monitored for virus shedding. Poliovirus (WPV2-MEF1) was detected in the stool of one, 4 days after exposure, later also in sewage samples. The operator was isolated at home and followed up until shedding stopped 29 days after exposure. No further transmission was detected.
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Duizer et al. (2017) conducted a case report in Accidental exposure to wild poliovirus type 2 (WPV2) (n=2). Accidental exposure to WPV2 was evaluated on Virus shedding (detection of WPV2 in stool). Following accidental exposure to a wild poliovirus type 2 spill, one of two fully vaccinated operators shed the virus for 29 days, with no further transmission detected.
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