Key result
Following an accidental spill, Sabin poliovirus type 3 was detected in the stool of only the most exposed of 5 vaccinated workers, with shedding restricted to less than 15 days.
Why the study?
Despite precautions to minimize environmental release, containment breaches can occur in facilities handling live poliovirus, requiring assessment of management and national response plans.
Case Report (n=5)
No
Monitoring of an accidental poliovirus exposure demonstrated that shedding in a vaccinated worker was brief, supporting the appropriateness of the national response plan.
Answers are grounded in this paper and cite their sources.
Brief shedding after accidental exposure supports containment protocols; leaves open validation in unvaccinated or outbreak populations.
The safe and secure containment of infectious poliovirus (PV) in facilities where live PV are handled is the condition to achieve and maintain poliomyelitis eradication. Despite precautions to minimize the risk of release of PV from such facilities to the environment, breaches of containment have already been documented. Here, we report the management of an incident that occurred on 30 November 2018 in a French vaccine manufacturing plant. Five adequately vaccinated operators were exposed to a Sabin poliovirus type 3 (PV3) spill. A microbiological risk assessment was conducted and the operators were monitored for PV shedding. On day 5 after exposure, Sabin PV3 was detected only in the stool sample of the most exposed worker. Shedding of Sabin PV3 (as detected by viral culture) was restricted to a very short period (less than 15 days). Monitoring of this incident was an opportunity to assess the relevance of our national response plan. We concluded that the measures undertaken and reported here were appropriate and proportional.
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Jeannoël et al. (2020) conducted a case report in Accidental exposure to Sabin poliovirus type 3 (n=5). Accidental exposure to concentrated Sabin poliovirus type 3 was evaluated on Sabin PV3 shedding in stool samples. Following an accidental spill, Sabin poliovirus type 3 was detected in the stool of only the most exposed of 5 vaccinated workers, with shedding restricted to less than 15 days.
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