Why the study?
What are the comparative circulatory and metabolic effects of epinephrine, nor-epinephrine, and insulin hypoglycemia, and how are they influenced by autonomic blocking agents?
Population
Healthy human subjects free of metabolic or cardiovascular disease, fasted for at least 12 hours without…
Comparison
Intravenous infusions of epinephrine… vs Baseline control periods for each subject.
Design
Other
Follow-up
Up to 80 minutes post-infusion/injection
Authors
Loading...
Alerts clinicians to epinephrine-specific metabolic effects in hypoglycemia; leaves open validation in contemporary randomized autonomic studies.
What are the comparative circulatory and metabolic effects of epinephrine, nor-epinephrine, and insulin hypoglycemia, and how are they influenced by autonomic blocking agents?
This study demonstrates that epinephrine and nor-epinephrine have distinct metabolic and hemodynamic profiles, and that the physiological response to insulin hypoglycemia is mediated by adrenal epinephrine release.
DiSalvo et al. (1956) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: