What question did this study set out to answer?

To identify the specific adrenergic receptor mechanisms responsible for epinephrine-mediated inhibition of insulin release and evaluate the influence of free fatty acids on insulin secretion in humans.

January 1, 1967Journal of Clinical InvestigationOpen Access

A Receptor Mechanism for the Inhibition Of Insulin Release by Epinephrine in Man*

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To identify the specific adrenergic receptor mechanisms responsible for epinephrine-mediated inhibition of insulin release and evaluate the influence of free fatty acids on insulin secretion in humans.
Infused healthy adult men and women with epinephrine at 6 µg per minute during targeted pharmacological blockades.
Administered phentolamine (alpha-adrenergic blocker), propranolol and butoxamine (beta-adrenergic blockers), or nicotinic acid (lipolysis blocker) alongside epinephrine and during 300 mg per minute glucose infusions.
Epinephrine infusion markedly decreased serum immunoreactive insulin levels, but concurrent administration of phentolamine completely abolished this inhibitory response.
Propranolol and butoxamine successfully blocked epinephrine-induced tachycardia, widened pulse pressure, and lipolysis, whereas phentolamine exerted no blocking effect on these parameters.
Lipolytic blockade via nicotinic acid failed to alter insulin or glucose responses to epinephrine or glucose infusion, contradicting the Randle glucose-fatty acid cycle hypothesis.

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Implication

Experimental study reveals alpha-adrenergic blockade prevents epinephrine-mediated insulin suppression in healthy adults, indicating an alpha-receptor inhibitory mechanism.

Cite This Study

Daniel Porte (1967) studied this question.

synapsesocial.com/papers/6a17fef61b114e5976b4bf37 https://doi.org/10.1172/jci105514

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Implication

Experimental study reveals alpha-adrenergic blockade prevents epinephrine-mediated insulin suppression in healthy adults, indicating an alpha-receptor inhibitory mechanism.

A Receptor Mechanism for the Inhibition Of Insulin Release by Epinephrine in Man*

Key Points

Discussion

Implication

Cite This Study

A Receptor Mechanism for the Inhibition Of Insulin Release by Epinephrine in Man*

Key Points

Discussion

Implication

Cite This Study

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