Key result
Angiotensin II stimulates G1 phase progression and dose-dependent cyclin D1 expression in human preadipocytes via the AT1 receptor, potentially contributing to adipocyte differentiation.
Population
Primary cultures of human preadipocytes from human adipose tissue
Comparison
Angiotensin II (AII) stimulation vs Untreated cells and pretreatment with…
Design
Preclinical
Authors
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May link AT1 signaling to human adipogenesis in vitro; leaves open relevance to obesity or cardiometabolic disease.
Angiotensin II promotes cell cycle progression in human preadipocytes via the AT1 receptor, suggesting a role in adipocyte differentiation.
David L. Crandall (1999) studied this question. Angiotensin II was evaluated on Cell cycle progression and cyclin D1 expression. Angiotensin II stimulates G1 phase progression and dose-dependent cyclin D1 expression in human preadipocytes via the AT1 receptor, potentially contributing to adipocyte differentiation.
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