Key result
Valsartan significantly reduced left ventricular hypertrophy and attenuated the overexpression of periostin and fibrotic markers in rats with diabetic cardiomyopathy.
Authors
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Animal data on periostin in rat DCM warrant caution against clinical extrapolation; leaves open mechanistic validation in humans.
Absolute Event Rate: 1.52% vs 1.81%
p-value: p=0.006
Guan et al. (2015) studied Diabetic cardiomyopathy (n=60). Valsartan vs. Vehicle (distilled water) was evaluated on Left ventricular coefficient (degree of left ventricular hypertrophy) (p=0.006). Valsartan significantly reduced left ventricular hypertrophy and attenuated the overexpression of periostin and fibrotic markers in rats with diabetic cardiomyopathy.
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