Key result
Hypertension and resistant hypertension were associated with higher serum levels of Urotensin-II, oxidative stress, and inflammation markers compared to normotensive controls (p < .001).
Why the study?
Urotensin-II, antioxidants, free radicals, and inflammatory biomarkers play an essential role in the cardiovascular system, but their patterns across normotensive, hypertensive, and resistant hypertensive patients needed investigation.
Are Urotensin-II, oxidative stress, and inflammation markers increased in hypertensive and resistant hypertensive patients compared to normotensive controls?
Observational (n=150)
Are Urotensin-II, oxidative stress, and inflammation markers increased in hypertensive and resistant hypertensive patients compared to normotensive controls?
Urotensin-II, oxidative stress, and inflammatory markers are significantly elevated in hypertensive and resistant hypertensive patients, suggesting a role in the pathophysiology of hypertension severity.
Elevated UII, oxidative stress, and inflammation in resistant hypertension; leaves open causal roles or biomarker utility.
Objective: Hypertension is a multi-factorial process prevalent in developed as well as in developing countries. Urotensin-II, different antioxidants, free radicals, and inflammatory biomarkers play an essential role in the cardiovascular system. The aim of this study is to investigate Urotensin-II, oxidative stress, and inflammation markers in normotensive, hypertensive, and resistant hypertensive patients.Methods: Fifty resistance hypertensive (rHT) patients, 50 hypertensive patients, and 50 age gender matched normotensive controls (NT-control) were enrolled. Urotensin-II (UII), total oxidant status (TOS), total antioxidant status (TAS), native thiol (NT), total thiol (TT), disulfide (DIS), interleukin 1 beta (IL1β), interleukin 6 (IL6), tumor necrosis factor-alpha (TNFα), high sensitive c reactive protein (hsCRP), high-density lipoprotein (HDL) low-density lipoprotein (LDL), and total cholesterol (TC) were evaluated.Results: Serum levels of UII, IL1β, IL6, TNFα, DIS, TOS, and OSI were found higher in rHT and HT as compared to NT-control (p < .001). On the contrary, serum levels of TT, TAS, and NT were lower in rHT and HT as compared to NT-control (p < .001). While TC, hsCRP, TOS, OSI, UII, IL1β, IL6, and TNFα levels increase from HT to rHT group (p < .001); TAS and NT levels decrease from HT to rHT group (p < .001).Conclusions: UII levels, oxidative stress, and inflammation are higher in rHT and HT, while antioxidants and thiol levels are lower than the NT-control. Our study clearly showed that rHT and HT are more susceptible to impaired states of antioxidants, oxidative stress, and free radicals.
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Güler et al. (2020) conducted an observational in Hypertension and resistant hypertension (n=150). Hypertension and resistant hypertension vs. Normotensive controls was evaluated on Serum levels of Urotensin-II, oxidative stress, and inflammation markers (p=< .001). Hypertension and resistant hypertension were associated with higher serum levels of Urotensin-II, oxidative stress, and inflammation markers compared to normotensive controls (p < .001).
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