Key result
Spontaneously hypertensive rats exhibited abnormal pancreatic microcirculation profiles, including impaired microvascular vasomotion and significantly reduced amplitudes of endothelial oscillators.
Why the study?
Pancreatic microcirculatory dysfunction emerged as a novel mechanism in hypertension development, but changes in pancreatic microcirculation profiles in hypertension remained unknown.
Answers are grounded in this paper and cite their sources.
Pancreatic microcirculatory changes in hypertensive rats are hypothesis-generating; leaves open translation to human disease or therapies.
Pancreatic microcirculatory dysfunction emerged as a novel mechanism in the development of hypertension. However, the changes of pancreatic microcirculation profiles in hypertension remain unknown. Pancreatic microcirculatory blood distribution pattern and microvascular vasomotion of spontaneously hypertensive rats (SHRs) and Wistar Kyoto rats (WKYs) were determined by laser Doppler. Wavelet transform analysis was performed to convert micro-hemodynamic signals into time-frequency domains, based on which amplitude spectral scalograms were constructed. The amplitudes of characteristic oscillators were compared between SHRs and WKYs. The expression of eNOS was determined by immunohistochemistry, and plasma nitrite/nitrate levels were measured by Griess reaction. Additionally, endothelin-1, malondialdehyde, superoxide dismutase and interleukin-6 were determined by enzyme-linked immunosorbent assay. SHRs exhibited a lower scale blood distribution pattern with decreased average blood perfusion, frequency and amplitude. Wavelet transform spectral analysis revealed significantly reduced amplitudes of endothelial oscillators. Besides reduced expression of eNOS, the blood microcirculatory chemistry complements micro-hemodynamic profiles as demonstrated by an increase in plasma nitrite/nitrate, endothelin-1, malondialdehyde, interleukin-6 and a decrease of superoxide dismutase in SHRs. Here, we described abnormal pancreatic microcirculation profiles in SHRs, including disarranged blood distribution pattern, impaired microvascular vasomotion and reduced amplitudes of endothelial oscillators.
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Song et al. (2020) studied Hypertension (n=12). Spontaneous hypertension vs. Normotensive Wistar-Kyoto rats was evaluated on Pancreatic microvascular vasomotion (average blood perfusion, amplitude, and frequency) (p=<0.05). Spontaneously hypertensive rats exhibited abnormal pancreatic microcirculation profiles, including impaired microvascular vasomotion and significantly reduced amplitudes of endothelial oscillators.
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