Key result
A long-term moderate magnesium-deficient diet progressively increased systolic blood pressure, pulse pressure, and age-induced deleterious effects on aorta composition and structure in rats.
Why the study?
Does a long-term moderate magnesium-deficient diet aggravate cardiovascular risks associated with aging in rats?
Population
Rats (adult 16 weeks old and old 96 weeks old)
Comparison
Long-term moderate magnesium-deficient diet or… vs Control diet (800 mg/kg)
Design
Preclinical
Follow-up
Up to 96 weeks of age
Authors
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Magnesium deficiency may worsen age-related vascular risks; hypothesis-generating in animals and leaves human translation open.
Does a long-term moderate magnesium-deficient diet aggravate cardiovascular risks associated with aging in rats?
Long-term moderate magnesium deficiency exacerbates age-related arterial stiffening and hypertension, increasing mortality in a rat model.
Adrian et al. (2008) studied Cardiovascular risks associated with aging. Moderate magnesium-deficient diet and magnesium-supplemented diet vs. Control diet (800 mg/kg) was evaluated on Cardiovascular and arterial functions and arterial wall structure. A long-term moderate magnesium-deficient diet progressively increased systolic blood pressure, pulse pressure, and age-induced deleterious effects on aorta composition and structure in rats.
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