Key result
During moderate exercise, 88% of asymptomatic patients with severe aortic stenosis had an abnormal increase in mean pulmonary artery pressure, suggesting exercise-induced pulmonary hypertension.
Why the study?
Optimal timing of aortic valve replacement remains difficult in asymptomatic, severe AS, warranting more accurate diagnostic methods to detect subtle ventricular impairment and evaluate diastolic function.
Does right heart catheterization during exercise unmask diastolic dysfunction in patients with asymptomatic, severe aortic stenosis?
Population
Patients with asymptomatic, severe AS and normal left ventricular ejection fraction
Comparison
Rest vs moderate exercise right heart catheterization
Design
Cross-sectional study
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Exercise RHC commonly reveals postcapillary PH in asymptomatic severe AS, suggesting unmasked diastolic dysfunction; hypothesis-generating for prospective validation.
Cross-Sectional (n=50)
Does right heart catheterization during exercise unmask diastolic dysfunction in patients with asymptomatic, severe aortic stenosis?
A large proportion of asymptomatic patients with severe aortic stenosis exhibit exercise-induced postcapillary pulmonary hypertension, suggesting unmasked diastolic dysfunction.
A 2022 study conducted a cross-sectional in Asymptomatic, severe aortic stenosis (n=50). Moderate exercise vs. Rest was evaluated on Increase in mean pulmonary artery pressure per increase in cardiac output of >3 mm Hg/L per minute. During moderate exercise, 88% of asymptomatic patients with severe aortic stenosis had an abnormal increase in mean pulmonary artery pressure, suggesting exercise-induced pulmonary hypertension.
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