Why the study?
Does allo- and xenomyoblast transplantation improve dystrophin expression in mdx mice, and what is the immune response?
Population
C57BL/10ScSn mdx/mdx mice and normal mice (C57BL/10SnJ+/+ and BALB/c+/+)
Design
Preclinical
Follow-up
6 weeks
Authors
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Immune reactions limit myoblast engraftment in mdx mice; leaves open whether immunosuppression can enable clinical translation in Duchenne muscular dystrophy.
Does allo- and xenomyoblast transplantation improve dystrophin expression in mdx mice, and what is the immune response?
Humoral and cellular immune reactions are responsible for the poor outcome of myoblast transplantation in mice, suggesting adequate immunosuppression is needed for Duchenne muscular dystrophy patients.
Asselin et al. (1995) studied this question.
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