Key result
Short-term immunosuppressive treatment with FK506 inhibited the transcription of IFN-gamma mRNA following MHC-noncompatible myoblast transplantation compared with untreated mice.
Why the study?
Does FK506 inhibit IFN-gamma mRNA expression following alloincompatible myoblast transplantation in mice?
Does FK506 inhibit IFN-gamma mRNA expression following alloincompatible myoblast transplantation in mice?
FK506 inhibits the cellular immune reaction, as indicated by decreased IFN-gamma mRNA expression, following alloincompatible myoblast transplantation in a mouse model.
Answers are grounded in this paper and cite their sources.
Supports short-term FK506 in murine transplantation models; extends preclinical data but leaves open human translation.
Myoblasts from C57BL/10SnJ+/+ were transplanted in major histocompatibility complex (MHC)-compatible mice (i.e., C57BL10SnJ+/+ and C57BL/10SnSc mdx/mdx) and in MHC-noncompatible (BALB/c+/+) mice. The recipients were killed 1-21 days after transplantation. C57BL10SnJ+/+ myoblasts were also transplanted in a few BALB/c+/+ mice treated with FK506 and killed 7 days thereafter. Our results showed that after MHC-noncompatible transplantation, interferon-gamma (IFN-gamma) mRNA expression is increased from day 5 to day 21, indicating the presence of a cellular immune reaction. Short-term immunosuppressive treatment with FK506 inhibited the transcription of IFN-gamma mRNA compared with that in untreated mice. Myoblast-specific antibodies were also detected 2 and 3 weeks after MHC-incompatible transplantation, indicating that the cellular immune reaction, revealed by the increase in IFN-gamma, was followed by a humoral reaction.
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Gu�rette et al. (1996) studied MHC-noncompatible myoblast transplantation. FK506 vs. untreated mice was evaluated on interferon-gamma (IFN-gamma) mRNA expression. Short-term immunosuppressive treatment with FK506 inhibited the transcription of IFN-gamma mRNA following MHC-noncompatible myoblast transplantation compared with untreated mice.
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