October 22, 2019European Journal of Preventive CardiologyOpen Access

Cardiac reinnervation influences exercise training outcomes in heart transplant patients

Q: What is the clinical evidence from this study?

Study design: Editorial. Population: Heart transplant (n=35). Intervention: Individualized exercise training program (aerobic, resistance, and flexibility) vs. Patients without evidence of cardiac reinnervation (comparison based on reinnervation status). Primary outcome: Ambulatory blood pressure and exercise tolerance (VO2max).

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Key result

A 12-week individualized exercise training program significantly reduced ambulatory blood pressure and improved exercise tolerance in heart transplant patients, with greater benefits seen in those with cardiac reinnervation.

Why the study?

Information remained scanty regarding the ability of heart transplant patients to participate in exercise training and how they respond to regular exercise interventions.

Does a 12-week exercise training program improve ambulatory blood pressure and exercise tolerance in heart transplant patients, and does cardiac reinnervation influence these outcomes?

Population

35 heart transplant patients aged 6-20 years old from a single medical center

Comparison

Cardiac reinnervation vs no cardiac reinnervation during a 12-week exercise training program

Design

Single-center cohort study

Follow-up

12-week

Authors

CACláudio Gil Soares de AraújoUniversidade do Estado do Rio de Janeiro JLJari A. LaukkanenPreventive Cardiology

Discussion

Member takes

Overview

Supports exercise training post-transplant; hypothesis-generating for reinnervation effects, needing RCTs before practice change.

Structured PICO

Does a 12-week exercise training program improve ambulatory blood pressure and exercise tolerance in heart transplant patients, and does cardiac reinnervation influence these outcomes?

Population

35 clinically stable and physically inactive heart transplant patients aged 6-20 years, at least one year post-surgery, who participated in a 12-week exercise program.

Intervention

12-week (three times a week) comprehensive and individualized exercise training program including aerobic, resistance, and flexibility exercises.

Comparator

Patients were divided into two groups based on presenting or not presenting evidence of cardiac reinnervation.

Outcome

Ambulatory blood pressure, exercise tolerance, and measured VO2max.surrogate

A 12-week exercise training program improves ambulatory blood pressure and exercise tolerance in pediatric and young adult heart transplant patients, with greater benefits observed in those with cardiac reinnervation.

Limitations

Exercise testing was carried out on a treadmill using the Naughton protocol rather than a ramp-like protocol on a cycle ergometer.
The study did not analyze the role of the oxygen pulse (VO2/heart rate) during test-retest cardiopulmonary exercise testing.

Cite This Study

Araújo et al. (2019) conducted an editorial in Heart transplant (n=35). Individualized exercise training program (aerobic, resistance, and flexibility) vs. Patients without evidence of cardiac reinnervation (comparison based on reinnervation status) was evaluated on Ambulatory blood pressure and exercise tolerance (VO2max). A 12-week individualized exercise training program significantly reduced ambulatory blood pressure and improved exercise tolerance in heart transplant patients, with greater benefits seen in those with cardiac reinnervation.

synapsesocial.com/papers/6a966d2e37dc33ab6afbb35d https://doi.org/10.1177/2047487319884374

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October 22, 2019European Journal of Preventive CardiologyOpen Access

Cardiac reinnervation influences exercise training outcomes in heart transplant patients

View Full Paper

Ask AI

Bookmark

Key result

Why the study?

Information remained scanty regarding the ability of heart transplant patients to participate in exercise training and how they respond to regular exercise interventions.

Does a 12-week exercise training program improve ambulatory blood pressure and exercise tolerance in heart transplant patients, and does cardiac reinnervation influence these outcomes?

Population

35 heart transplant patients aged 6-20 years old from a single medical center

Comparison

Cardiac reinnervation vs no cardiac reinnervation during a 12-week exercise training program

Design

Single-center cohort study

Follow-up

12-week

Authors

CACláudio Gil Soares de AraújoUniversidade do Estado do Rio de Janeiro JLJari A. LaukkanenPreventive Cardiology

Discussion

Member takes

Overview

Supports exercise training post-transplant; hypothesis-generating for reinnervation effects, needing RCTs before practice change.

Structured PICO

Does a 12-week exercise training program improve ambulatory blood pressure and exercise tolerance in heart transplant patients, and does cardiac reinnervation influence these outcomes?

Population

35 clinically stable and physically inactive heart transplant patients aged 6-20 years, at least one year post-surgery, who participated in a 12-week exercise program.

Intervention

12-week (three times a week) comprehensive and individualized exercise training program including aerobic, resistance, and flexibility exercises.

Comparator

Patients were divided into two groups based on presenting or not presenting evidence of cardiac reinnervation.

Outcome

Ambulatory blood pressure, exercise tolerance, and measured VO2max.surrogate

Limitations

Exercise testing was carried out on a treadmill using the Naughton protocol rather than a ramp-like protocol on a cycle ergometer.
The study did not analyze the role of the oxygen pulse (VO2/heart rate) during test-retest cardiopulmonary exercise testing.

Cite This Study

synapsesocial.com/papers/6a966d2e37dc33ab6afbb35d https://doi.org/10.1177/2047487319884374

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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