What is the clinical evidence from this study?

Population: Essential hypertension (n=95). Intervention: Perindopril vs. Hydrochlorothiazide. Primary outcome: Oxidative stress parameters (SOD-1, CAT, MDA, Cp oxidase, carbonyl groups, NO).

What question did this study set out to answer?

To compare the effects of the ACE inhibitor perindopril and the diuretic hydrochlorothiazide on blood oxidative stress markers in elderly patients with essential hypertension.

July 18, 2006Clinical and Experimental Pharmacology and Physiology

Effects of Perindopril and Hydrochlorothiazide on Selected Indices of Oxidative Stress in the Blood of Elderly Patients With Essential Hypertension

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Key result

Perindopril, but not hydrochlorothiazide, significantly increased SOD-1 and CAT activities and decreased MDA concentration and Cp oxidase activity in elderly hypertensive patients.

Why the study?

Does perindopril compared to hydrochlorothiazide improve oxidative stress parameters in elderly patients with essential hypertension?

Population

45 elderly patients with essential hypertension, along with 25 young and 25 elderly normotensive control…

Comparison

Perindopril for 45 days (n=25) vs Hydrochlorothiazide for 45 days (n=20)

Design

Cohort

Follow-up

45 days

Authors

KKKornelia Kędziora–KornatowskaKazimierz Wielki University in Bydgoszcz JCJolanta CzuczejkoNicolaus Copernicus University KSKarolina Szewczyk‐GolecNicolaus Copernicus University

Discussion

Member takes

Implication

May suggest antioxidant effects favoring perindopril in elderly hypertension; leaves open clinical outcome benefits versus hydrochlorothiazide.

Key Points

To compare the effects of the ACE inhibitor perindopril and the diuretic hydrochlorothiazide on blood oxidative stress markers in elderly patients with essential hypertension.
Evaluated 45 elderly patients with essential hypertension before and after 45 days of treatment with either perindopril (n=25) or hydrochlorothiazide (n=20).
Compared patient parameters against 25 young and 25 elderly normotensive control subjects, measuring blood pressure, nitric oxide, carbonyl groups, malondialdehyde (MDA), ceruloplasmin oxidase, Cu-Zn superoxide dismutase (SOD-1), and catalase (CAT).
Hypertensive subjects displayed higher baseline MDA, carbonyl groups, and ceruloplasmin oxidase activity, alongside lower nitric oxide, SOD-1, and CAT activities relative to elderly controls.
Perindopril treatment significantly increased SOD-1 and CAT activities while decreasing MDA concentration and ceruloplasmin oxidase activity; hydrochlorothiazide did not alter these parameters.
Both perindopril and hydrochlorothiazide therapies significantly reduced carbonyl group concentrations and increased nitric oxide levels after 45 days.

Structured PICO

Does perindopril compared to hydrochlorothiazide improve oxidative stress parameters in elderly patients with essential hypertension?

Population

95 subjects, including 45 elderly patients with essential hypertension and 50 normotensive controls, evaluated for oxidative stress parameters after 45 days of therapy.

Intervention

Perindopril for 45 days (n=25)

Comparator

Hydrochlorothiazide for 45 days (n=20)

Outcome

Selected oxidative stress parameters in the blood (nitric oxide, carbonyl groups, malondialdehyde concentrations, and activity of ceruloplasmin oxidase, Cu-Zn superoxide dismutase, and catalase) and blood pressure at 45 dayssurrogate

Perindopril, unlike hydrochlorothiazide, provides significant antioxidant benefits in elderly patients with essential hypertension, suggesting additional vascular protective effects beyond blood pressure lowering.

Cite This Study

Kędziora–Kornatowska et al. (2006) studied Essential hypertension (n=95). Perindopril vs. Hydrochlorothiazide was evaluated on Oxidative stress parameters (SOD-1, CAT, MDA, Cp oxidase, carbonyl groups, NO). Perindopril, but not hydrochlorothiazide, significantly increased SOD-1 and CAT activities and decreased MDA concentration and Cp oxidase activity in elderly hypertensive patients.

synapsesocial.com/papers/6a96717f1642389cd3f6928a https://doi.org/10.1111/j.1440-1681.2006.04436.x

Topics

Hypertension management

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Implication

May suggest antioxidant effects favoring perindopril in elderly hypertension; leaves open clinical outcome benefits versus hydrochlorothiazide.

Effects of Perindopril and Hydrochlorothiazide on Selected Indices of Oxidative Stress in the Blood of Elderly Patients With Essential Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Effects of Perindopril and Hydrochlorothiazide on Selected Indices of Oxidative Stress in the Blood of Elderly Patients With Essential Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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