Why the study?
Does pregnancy delay the rejection of heterotopic heart allografts in rabbits and rats?
Does pregnancy delay the rejection of heterotopic heart allografts in rabbits and rats?
Pregnancy-induced immunosuppression does not prolong the survival of heterotopic heart allografts in rabbit and rat models.
The effect of pregnancy on the rejection time and pattern of heterotopic heart allografts has been studied in outbred rabbits and in inbred rats. Female rabbits pregnant by donor‐unrelated males rejected within normal periods of time. In the rat system recipients were transplanted during 1) intrastrain pregnancy 2) interstrain non donorrelated pregnancy and 3) during interstrain donor‐specific pregnancy. No significant prolongation of allograft survival time was found regardless of the genetic constitution of the foetuses. It is concluded that pregnancy‐induced immunosuppression cannot explain the success of the foetal allograft to survive the period of gestation.
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Heron et al. (1971) studied this question.
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