September 1, 1995The Journal of Infectious Diseases

Oral Inoculation of Mice with Low Doses of Microencapsulated, Noninfectious Rotavirus Induces Virus-Specific Antibodies in Gut-Associated Lymphoid Tissue

Q: What is the clinical evidence from this study?

Study design: Other. Population: Rotavirus immunization. Intervention: Microencapsulated inactivated rotavirus (iRRV) vs. Unencapsulated inactivated RRV. Primary outcome: Virus-specific IgA production by small intestine lamina propria lymphocytes.

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Key result

Oral inoculation with microencapsulated inactivated rotavirus induced virus-specific IgA in gut-associated lymphoid tissue, whereas unencapsulated virus did not.

Authors

CKC. A. KhouryChildren's Hospital of Philadelphia CMCharlotte A. MoserChildren's Hospital of Philadelphia TSTully J. SpeakerTemple University

Discussion

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Implication

Microencapsulation may enhance oral rotavirus immunogenicity in animals; hypothesis-generating for human mucosal vaccines, with no practice change warranted.

PICO

Population

Mice orally inoculated with noninfectious rotavirus to evaluate humoral immune responses.

Intervention / Comparator

Microencapsulated inactivated rotavirus (iRRV) vs Unencapsulated inactivated RRV (1.75 or 0.35 microgram)

Primary Outcome

Virus-specific IgA production by small intestine lamina propria lymphocytes

Cite This Study

Khoury et al. (1995) studied Rotavirus immunization. Microencapsulated inactivated rotavirus (iRRV) vs. Unencapsulated inactivated RRV was evaluated on Virus-specific IgA production by small intestine lamina propria lymphocytes. Oral inoculation with microencapsulated inactivated rotavirus induced virus-specific IgA in gut-associated lymphoid tissue, whereas unencapsulated virus did not.

synapsesocial.com/papers/6a9679ae31394ac286fbbd7e https://doi.org/10.1093/infdis/172.3.870

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Implication

Microencapsulation may enhance oral rotavirus immunogenicity in animals; hypothesis-generating for human mucosal vaccines, with no practice change warranted.

Oral Inoculation of Mice with Low Doses of Microencapsulated, Noninfectious Rotavirus Induces Virus-Specific Antibodies in Gut-Associated Lymphoid Tissue

Discussion

Member takes

Implication

PICO

Cite This Study

Oral Inoculation of Mice with Low Doses of Microencapsulated, Noninfectious Rotavirus Induces Virus-Specific Antibodies in Gut-Associated Lymphoid Tissue

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider