Key result
The homozygous normal genotype of the VEGF rs2010963 polymorphism was independently associated with a higher incidence of diffuse in-stent restenosis after bare metal stent implantation.
Why the study?
Are VEGF gene polymorphisms (rs2010963 and rs6999447) associated with the occurrence of diffuse in-stent restenosis in patients treated with bare metal stents?
Case-Control (n=205)
Are VEGF gene polymorphisms (rs2010963 and rs6999447) associated with the occurrence of diffuse in-stent restenosis in patients treated with bare metal stents?
The rs2010963 polymorphism in the VEGF gene is independently associated with a higher incidence of diffuse in-stent restenosis following bare metal stent implantation.
Background. In-stent restenosis (ISR) is the gradual narrowing of the vessel lumen after coronary stent implantation due to the increase in vascular smooth muscle cell proliferation. Vascular endothelial growth factor (VEGF) protein plays an important role in this process. Our aim was to analyze the association of single nucleotide polymorphisms of the VEGF gene (rs2010963 and rs6999447) with the occurrence of ISR after coronary artery bare metal stent (BMS) implantation. Methods. 205 patients with a history of BMS implantation and a repeated coronarography were prospectively enrolled. Patients were assigned to diffuse restenosis group ( n=105 ) and control group ( n=100 ) and VEGF genotypes were determined. Results. Diffuse ISR was significantly more frequently observed in patients with homozygous normal genotype of rs2010963 polymorphism, and this polymorphism was independently associated with diffuse ISR. Conclusions. RS2010963 is associated with higher incidence of development of diffuse coronary ISR in patients treated with BMS implantation.
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Bagyura et al. (2017) conducted a case-control in In-stent restenosis after bare metal stent implantation (n=205). VEGF gene polymorphisms (rs2010963 and rs6999447) vs. Control group (no diffuse restenosis) was evaluated on Occurrence of diffuse in-stent restenosis. The homozygous normal genotype of the VEGF rs2010963 polymorphism was independently associated with a higher incidence of diffuse in-stent restenosis after bare metal stent implantation.
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