Population
Anesthetized sham and chronic heart failure (CHF) rats
Comparison
Stimulation of RVLM AT1R and AT2R by angiotensin… vs Sham rats and artificial cerebrospinal fluid
Design
Preclinical
Authors
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May implicate RVLM AT2R loss in CHF sympathoexcitation; leaves open any therapeutic role pending human studies.
Downregulation of AT2R in the rostral ventrolateral medulla contributes to sympathoexcitation in chronic heart failure, suggesting a protective inhibitory role of AT2R on sympathetic outflow.
Gao et al. (2008) studied this question.
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