Why the study?
Does glucose-lowering therapy improve coronary endothelial function and slow the progression of coronary artery calcification in patients with type 2 diabetes mellitus?
Population
39 participants, including 22 with type 2 diabetes mellitus and 17 healthy controls.
Comparison
Glucose-lowering therapy vs Healthy controls and baseline measurements
Design
Cohort
Follow-up
mean 14 +/- 1.9 months
Authors
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Glucose lowering was associated with slower CAC progression via endothelial function; hypothesis-generating and requires randomized confirmation in T2DM.
Does glucose-lowering therapy improve coronary endothelial function and slow the progression of coronary artery calcification in patients with type 2 diabetes mellitus?
In patients with type 2 diabetes, glucose-lowering treatment improves coronary endothelial function, which independently predicts slowed progression of coronary artery calcification.
Schindler et al. (2009) studied this question.
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