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September 1, 2026Combinatorial Chemistry & High Throughput Screening

Compound Fufangteng Oral Liquid improves cardiac function and lowers NT-proBNP in CHF animal models.

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Why the study?

Current therapies for chronic heart failure remain limited, and the multi-target effects of Compound Fufangteng Oral Liquid across different CHF models remain unclear.

Does Compound Fufangteng Oral Liquid improve cardiac function and reduce myocardial damage in rat/mouse models of chronic heart failure?

Population

Rats/mice in three CHF models

Comparison

CFFOL vs blank control vs untreated model vs captopril

Design

Randomized unblinded animal study

Key result

Compound Fufangteng Oral Liquid significantly improved cardiac function, reduced serum NT-proBNP and inflammatory markers, and alleviated myocardial pathological changes in CHF animal models.

Authors

YLYin LuGuangxi UniversityHCHongTao ChenGuangxi UniversityLDLiangxing DingGuangxi University

Discussion

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Overview

Preclinical data support CFFOL efficacy in rodent CHF models; hypothesis-generating, clinical trials required before any human use.

Key Points

  • To investigate the therapeutic efficacy and dose-response relationship of Compound Fufangteng Oral Liquid (CFFOL) across three distinct chronic heart failure models.
  • Established three rodent models of chronic heart failure representing qi deficiency, cardiac overload, and myocardial injury.
  • Randomized animals into blank control, model, captopril, and CFFOL treatment groups.
  • Evaluated cardiac function (EF, FS) using echocardiography, quantified serum NT-proBNP, TNF-α, and myocardial enzymes (CK, LDH, α-HBDH) via ELISA, and examined tissue histology with H&E staining.
  • CFFOL significantly improved cardiac function by increasing ejection fraction and fractional shortening across the heart failure models.
  • Treatment markedly reduced serum levels of heart stress and injury markers (NT-proBNP, CK, LDH, α-HBDH) and the inflammatory cytokine TNF-α.
  • Histopathological analysis revealed alleviation of myocardial fiber disorganization, vacuolization, nuclear condensation, and fibrosis.

Structured PICO

Does Compound Fufangteng Oral Liquid improve cardiac function and reduce myocardial damage in rat/mouse models of chronic heart failure?

P
Population
Male rats and mice with established chronic heart failure models (qi deficiency, cardiac overload, myocardial injury).
I
Intervention
Compound Fufangteng Oral Liquid (CFFOL)
C
Comparator
Blank control, untreated model group, and captopril
O
Outcome
Cardiac function (EF, FS) assessed by echocardiographysurrogate

Compound Fufangteng Oral Liquid demonstrates cardioprotective effects and improves cardiac function across multiple preclinical models of chronic heart failure.

Limitations

  • Lack of blinding
  • Male-only animals
  • No pharmacokinetic data
  • Mechanistic claims remain speculative as molecular assays were not performed
  • lack of blinding
  • male-only animals
  • no pharmacokinetic data
  • mechanistic claims remain speculative as molecular assays were not performed

Cite This Study

Lu et al. (2026) studied Chronic Heart Failure. Compound Fufangteng Oral Liquid (CFFOL) vs. Blank control, model, captopril was evaluated on Cardiac function (EF, FS), serum NT-proBNP, TNF-α, and myocardial enzymes. Compound Fufangteng Oral Liquid significantly improved cardiac function, reduced serum NT-proBNP and inflammatory markers, and alleviated myocardial pathological changes in CHF animal models.

synapsesocial.com/papers/6a969a7f535111e2d4ce8cd1https://doi.org/10.2174/0113862073473456260804042252
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