Key result
Increased severity of coronary artery disease, from normal coronary arteries to acute coronary syndrome, was significantly associated with prolonged Tp-e interval (66 vs 71 vs 76 ms; p<0.001) and increased Tp-e/QT and Tp-e/QTc ratios.
Why the study?
CAD causes electrical heterogeneity and ventricular arrhythmia via ischemia-linked ventricular repolarization abnormalities, but the impact of CAD spectrum and severity on ventricular repolarization required investigation.
Does the spectrum and severity of coronary artery disease impact ventricular repolarization parameters (Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios)?
Cross-Sectional (n=376)
Single-blind
Yes
Does the spectrum and severity of coronary artery disease impact ventricular repolarization parameters (Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios)?
Absolute Event Rate: 76% vs 66%
p-value: p=<0.001
This study investigates whether the severity and clinical spectrum of coronary artery disease correlate with electrocardiographic markers of ventricular repolarization abnormalities.
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Kahraman et al. (2021) conducted a cross-sectional in Coronary Artery Disease (n=376). Coronary Artery Disease spectrum (SCAD and ACS) vs. Normal coronary arteries was evaluated on Tp-e interval (ms) (p=<0.001). Increased severity of coronary artery disease, from normal coronary arteries to acute coronary syndrome, was significantly associated with prolonged Tp-e interval (66 vs 71 vs 76 ms; p<0.001) and increased Tp-e/QT and Tp-e/QTc ratios.
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