Key result
Reserpine and chlorothiazide significantly lowered resting blood pressure but failed to diminish the magnitude of pressure and heart rate elevations resulting from physical or psychological stimuli.
Why the study?
Do reserpine and chlorothiazide reduce pressor and pulse rate responses to noxious stimuli in hypertensive patients?
Do reserpine and chlorothiazide reduce pressor and pulse rate responses to noxious stimuli in hypertensive patients?
Reserpine and chlorothiazide lower resting blood pressure but do not blunt the cardiovascular response to physical or psychological noxious stimuli in hypertensive patients.
May not blunt pressor responses despite resting BP lowering; leaves open optimal strategies for stress-related hypertension control.
The pressor and pulse rate responses to three standardized noxious stimuli were determined in groups of hypertensive patients receiving reserpine and chlorothiazide, alone and in combination. Although the drugs caused a significant decline in resting blood pressure, they failed to diminish the actual magnitude of the elevations in pressure and heart rate resulting from either physical or psychological stimuli. The possible physiological interpretations and the therapeutic implications of these data have been pointed out.
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Alvin P. Shapiro (1962) studied Hypertension. Reserpine and chlorothiazide (alone and in combination) was evaluated on Pressor and pulse rate responses to standardized noxious stimuli. Reserpine and chlorothiazide significantly lowered resting blood pressure but failed to diminish the magnitude of pressure and heart rate elevations resulting from physical or psychological stimuli.
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