Reserpine and chlorothiazide significantly lowered resting blood pressure but failed to diminish the magnitude of pressure and heart rate elevations resulting from physical or psychological stimuli.
The pressor and pulse rate responses to three standardized noxious stimuli were determined in groups of hypertensive patients receiving reserpine and chlorothiazide, alone and in combination. Although the drugs caused a significant decline in resting blood pressure, they failed to diminish the actual magnitude of the elevations in pressure and heart rate resulting from either physical or psychological stimuli. The possible physiological interpretations and the therapeutic implications of these data have been pointed out.
Alvin P. Shapiro (1962) studied Hypertension. Reserpine and chlorothiazide (alone and in combination) was evaluated on Pressor and pulse rate responses to standardized noxious stimuli. Reserpine and chlorothiazide significantly lowered resting blood pressure but failed to diminish the magnitude of pressure and heart rate elevations resulting from physical or psychological stimuli.