Key result
Hypertensive subjects exhibited a significantly greater mean blood pressure increase in response to intravenous angiotensin II compared to normotensive subjects (39.6 vs 26.2 mm Hg, p<0.001).
Cross-Sectional (n=113)
No
Intrinsic factors may govern pressor reactivity independent of basal BP; leaves open reactivity-targeted interventions in hypertension.
In earlier studies, the influence of various host affecting the pressor responses to noxious stimuli in hypertensive and normotensive subjects was investigated. Information was obtained indicating that intrinsic factors predominate in determining the type and severity of such pressor responses (1). It also was demonstrated that lowering basal blood pressure in the hypertensive patient with therapeutic doses of reserpine and chlorothiazide did not decrease these responses (2). The present studies represent a continuing effort to define the factors determining patterns of pressor response to noxious stimuli, with particular attention to the physiologic mechanisms that mediate these responses. As in previous studies, the cold pressor test was assumed to measure the neurogenic component, and this response was
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Shapiro et al. (1963) conducted a cross-sectional in Hypertension and Diabetes (n=113). Intravenous angiotensin II vs. Normotensive subjects was evaluated on Mean blood pressure response to angiotensin II (p=<0.001). Hypertensive subjects exhibited a significantly greater mean blood pressure increase in response to intravenous angiotensin II compared to normotensive subjects (39.6 vs 26.2 mm Hg, p<0.001).
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