Key result
Plasma from hypertensive patients injected into nephrectomized rats significantly increased vascular sensitivity to angiotensin and norepinephrine compared to normotensive plasma.
Why the study?
Does plasma from hypertensive patients increase vascular sensitivity to pressor agents in nephrectomized rats compared to plasma from normotensive subjects?
Does plasma from hypertensive patients increase vascular sensitivity to pressor agents in nephrectomized rats compared to plasma from normotensive subjects?
This preclinical study provides evidence for a circulating factor, likely of renal origin, in the plasma of hypertensive patients that increases vascular sensitivity to pressor agents.
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Does not alter hypertension management; hypothesis-generating for a circulating vascular sensitizer requiring human validation.
Mizukoshi et al. (1972) studied Hypertension. Plasma from hypertensive patients vs. Plasma from normotensive individuals was evaluated on Vascular sensitivity to angiotensin and norepinephrine and mean arterial blood pressure. Plasma from hypertensive patients injected into nephrectomized rats significantly increased vascular sensitivity to angiotensin and norepinephrine compared to normotensive plasma.
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