Upfront treatment options for stage III and IV larynx Squamous Cell Carcinoma (SCC) include laryngectomy or chemoradiation (CRT). The functional consequence of laryngectomy is debilitating (instant loss of voice in most cases) and significantly affects patients' quality of life. This study examined the rate of organ preservation and associated late morbidity for T3N+/-M0 glottic SCC treated with upfront concurrent CRT.
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Lin et al. (2013) studied this question.
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