Key result
Molsidomine metabolites, particularly SIN-1A, elicited concentration-dependent vasorelaxation in isolated dog blood vessels, with lower EC50 values than nitroglycerin.
Population
Isolated dog blood vessels
Comparison
Molsidomine and its metabolites vs Nitroglycerin and other vasodilators
Design
Preclinical
Authors
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Does not support clinical use of molsidomine metabolites; leaves open translation from canine vessels to human therapy.
The vasodilating action of molsidomine is mediated by its active metabolites, particularly SIN-1A, which directly relaxes vascular smooth muscle likely via a nitric oxide moiety.
Muramatsu et al. (1983) studied this question. Molsidomine (SIN-10) and its metabolites (SIN-1, SIN-1A) vs. Nitroglycerin was evaluated on Vasorelaxation of isolated dog blood vessels. Molsidomine metabolites, particularly SIN-1A, elicited concentration-dependent vasorelaxation in isolated dog blood vessels, with lower EC50 values than nitroglycerin.
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