January 1, 1989Journal of Cardiovascular Pharmacology

Modulation of the Vasodilator Action of SIN-1 by the Endothelium

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Population

Rabbit femoral artery and thoracic aorta segments

Comparison

SIN-1 (sydnonimine) application vs Presence versus absence of endothelium, or…

Design

Preclinical

Authors

RBRudi BusseVascular Medicine UPUlrich PohlCentre of Experimental Medicine of the Slovak Academy of Sciences AMAlexander MülschGoethe University Frankfurt

Discussion

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Implication

Endothelial factors may attenuate SIN-1 vasodilation in intact vessels; hypothesis-generating for NO donor pharmacology in animal models.

Structured PICO

Population

Rabbit femoral artery and thoracic aorta segments

Intervention

SIN-1 (sydnonimine) application

Comparator

Presence versus absence of endothelium, or presence versus absence of EDRF synthesis inhibitors (gossypol or NG-nitro-L-arginine)

Outcome

Vasodilatation and accumulation of cyclic GMPsurrogate

The endothelium modulates vascular reactivity to SIN-1, likely mediated by EDRF or another endothelial substance altering cyclic GMP metabolism or action in vascular smooth muscle.

Cite This Study

Busse et al. (1989) studied this question.

synapsesocial.com/papers/6a86b86bbb0787ff27ca0419 https://doi.org/10.1097/00005344-198906152-00015

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Modulation of the Vasodilator Action of SIN-1 by the Endothelium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Modulation of the Vasodilator Action of SIN-1 by the Endothelium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider