January 1, 1989Journal of Cardiovascular Pharmacology

SIN-1 Stimulates the Production of Cyclic GMP but not Cyclic AMP in Porcine Aortic Endothelial Cells

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Why the study?

Does SIN-1 stimulate the production of cyclic AMP and cyclic GMP in cultured porcine aortic endothelial cells?

Population

First or second passage cultured porcine aortic endothelial cells

Comparison

SIN-1 (a metabolite of molsidomine) vs Human alpha-natriuretic polypeptide, methylene…

Design

Preclinical

Authors

VSValérie B. SchiniBaylor College of Medicine PVP. M. VanhoutteMayo Clinic

Discussion

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Implication

Hypothesis-generating for NO donor selectivity in endothelium; leaves open in vivo translation and clinical relevance.

Structured PICO

Does SIN-1 stimulate the production of cyclic AMP and cyclic GMP in cultured porcine aortic endothelial cells?

Population

First or second passage cultured porcine aortic endothelial cells

Intervention

SIN-1 (a metabolite of molsidomine)

Comparator

Human alpha-natriuretic polypeptide, methylene blue, and hemoglobin (used as mechanistic controls/inhibitors)

Outcome

Production of adenosine-3',5'-cyclic monophosphate (cyclic AMP) and guanosine-3',5'-cyclic monophosphate (cyclic GMP)surrogate

SIN-1 stimulates cyclic GMP accumulation in endothelial cells via the spontaneous release of nitric oxide and subsequent activation of soluble guanylate cyclase.

Cite This Study

Schini et al. (1989) studied this question.

synapsesocial.com/papers/6a90ded6f69e67dea43609be https://doi.org/10.1097/00005344-198906152-00017

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SIN-1 Stimulates the Production of Cyclic GMP but not Cyclic AMP in Porcine Aortic Endothelial Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

SIN-1 Stimulates the Production of Cyclic GMP but not Cyclic AMP in Porcine Aortic Endothelial Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider