Population
Rat isolated mesenteric arteries pre-constricted with phenylephrine (1-3 microM)
Comparison
3-morpholino-sydnonimine (SIN-1; 0.01-10 microM) vs Endothelium-intact vs denuded segments, and…
Design
Preclinical
Authors
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May implicate charybdotoxin-sensitive K+ channels in NO-mediated relaxation; hypothesis-generating for human vascular pharmacology.
In rat isolated mesenteric arteries, SIN-1-evoked relaxation is heavily dependent on the activation of charybdotoxin-sensitive potassium channels in the presence of basal endothelium-derived NO.
Plane et al. (1996) studied this question.
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