Key result
Among acutely ill hospitalized patients, VTE rates during hospitalization and 6 months postdischarge were 6.3% for those with baseline renal disease and 3.8% for those without.
Why the study?
The study sought to examine venous thromboembolism prophylaxis patterns and risk for events during hospitalization and outpatient care among acutely ill medical patients, stratified by age and renal disease status.
Cohort (n=17,895)
A majority of acutely ill hospitalized patients in the US do not receive VTE prophylaxis, and the risk of VTE remains elevated for 30 to 40 days post-admission regardless of age or renal status.
Answers are grounded in this paper and cite their sources.
VTE prophylaxis patterns vary by age and renal status; hypothesis-generating for tailored strategies pending prospective trials.
The objectives of this study were to examine venous thromboembolism (VTE) prophylaxis patterns and risk for VTE events during hospitalization and in the outpatient continuum of care among patients hospitalized for acute illnesses in the United States with stratification by different age groups and renal disease status. Acutely ill hospitalized patients were identified from the MarketScan databases (January 1, 2012-June 30, 2015) and grouped by age (<65, 65-74, ≥75 years old) and whether or not they had a baseline diagnosis of renal disease, separately. Of acutely ill hospitalized patients, 60.1% (n = 10 748) were <65 years old, 15.7% (n = 2803) were 65 to 74 years old, and 24.3% (n = 4344) were ≥75 years old; 32.9% (n = 5892) had baseline renal disease. Among the study cohorts, the majority of patients received no VTE prophylaxis regardless of age or baseline renal status (52.1%-63.6%). Rates of VTE during hospitalization and in the 6 months postdischarge were 4.7%, 4.6%, and 4.5% for patients <65, 65 to 74, and ≥75 years old, respectively, and 6.3% and 3.8% for patients with and without baseline renal disease. The risk for VTE was elevated for 30 to 40 days after index admission regardless of age and renal disease status.
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Amin et al. (2019) conducted a cohort in Acute illnesses requiring hospitalization (n=17,895). Baseline renal disease vs. No baseline renal disease was evaluated on VTE events during hospitalization and in the 6 months postdischarge. Among acutely ill hospitalized patients, VTE rates during hospitalization and 6 months postdischarge were 6.3% for those with baseline renal disease and 3.8% for those without.
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