Key result
Intranasal, intragastric, and oral inoculation of untreated human stools produced typical poliomyelitis in 4 chimpanzees, including 2 instances where the olfactory portal was ruled out.
Poliomyelitis virus can enter and cause disease via intranasal, intragastric, and oral routes in chimpanzees, independent of the olfactory tracts.
Chimpanzee data support multiple polio entry routes; leaves open human translation and prevention implications.
Typical poliomyelitis has been produced in 4 chimpanzees by the intranasal, intragastric, and oral inoculation of untreated human stools. In 2 instances the olfactory portal was ruled out by section of both olfactory tracts.
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Howe et al. (1940) studied this question. Intranasal, intragastric, and oral inoculation of untreated human stools produced typical poliomyelitis in 4 chimpanzees, including 2 instances where the olfactory portal was ruled out.
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