Key result
Emergent open-heart surgery followed by proton beam radiotherapy for local recurrence successfully treated a life-threatening primary cardiac undifferentiated pleomorphic sarcoma, with the patient surviving over one year.
Case Report (n=1)
No
Proton beam radiotherapy may be an effective treatment for local recurrence of primary cardiac undifferentiated pleomorphic sarcoma following surgical resection.
May support proton beam radiotherapy for recurrent cardiac sarcoma post-resection; hypothesis-generating and requires prospective validation.
A 41-year-old man was admitted with acute heart failure and shock status. An echocardiogram showed a mobile tumor obstructing blood flow through the mitral valve with a stalk on the posterior left atrium (LA) wall. Emergent open-heart surgery was performed to resect the tumor (77×36×30 mm). Histological examination confirmed that it was an undifferentiated pleomorphic sarcoma. Unfortunately, positron emission tomography performed five months after surgery demonstrated a local recurrence around the right pulmonary vein and LA. We performed proton beam radiotherapy to treat the local recurrence, and it was effective. The patient has survived more than one year since the first life-threatening heart failure episode.
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Abe et al. (2014) conducted a case report in Primary cardiac undifferentiated pleomorphic sarcoma (n=1). Emergent open-heart surgery and proton beam radiotherapy was evaluated on Survival and tumor recurrence. Emergent open-heart surgery followed by proton beam radiotherapy for local recurrence successfully treated a life-threatening primary cardiac undifferentiated pleomorphic sarcoma, with the patient surviving over one year.
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