Key result
Radioiodinated Hippuran distribution showed the first compartment exceeded plasma volume, with up to 60% biliary excretion in 24 hours in bilaterally nephrectomized dogs.
Understanding the distribution and excretion of Hippuran I131, including its compartment analysis, can improve the accuracy and interpretation of radiorenograms.
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May refine radiorenogram interpretation in anuria models; leaves open human translation.
Blaufox et al. (1963) studied Nephrectomy (n=6). Radioiodinated Hippuran vs. Unilateral vs bilateral nephrectomy was evaluated on Disappearance of I131 from plasma and distribution. Radioiodinated Hippuran distribution showed the first compartment exceeded plasma volume, with up to 60% biliary excretion in 24 hours in bilaterally nephrectomized dogs.
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