Key result
Application of a normal-mode-based X-ray crystallographic refinement method established the complete structure of full-length Kv1.2 in its native form, revealing a 10 Å hydrophobic layer.
The application of a novel normal-mode-based X-ray crystallographic refinement method successfully resolved the full-length structure of the Kv1.2 potassium channel, providing mechanistic insights into voltage sensing.
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Advances Kv1.2 structural insights in animal models; leaves open human translation and therapeutic relevance.
Chen et al. (2010) studied this question. Normal-mode-based X-ray crystallographic refinement vs. Conventional isotropic X-ray crystallographic refinement was evaluated on Structural resolution of the full-length Kv1.2 channel. Application of a normal-mode-based X-ray crystallographic refinement method established the complete structure of full-length Kv1.2 in its native form, revealing a 10 Å hydrophobic layer.
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