Key result
Partially purified natriuretic factor from rat kidney dose-dependently inhibits frog skin SCC and Na-K-ATPase, with its activity destroyed by trypsin but not chymotrypsin.
This preclinical study demonstrates the partial purification of a natriuretic factor from rat kidneys that dose-dependently inhibits Na-K-ATPase.
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No clinical implications from this animal study; leaves open a renal natriuretic factor's identity and role in mammals.
Raghavan et al. (1980) studied this question. Partially purified natriuretic factor from rat kidney dose-dependently inhibits frog skin SCC and Na-K-ATPase, with its activity destroyed by trypsin but not chymotrypsin.