Key result
Immunohistochemical analysis in rats aged 1 to 14 days revealed heterochronic development of the terminal synaptic network, with early cholinergic predominance and subsequent active nerve fiber growth.
Why the study?
The study was conducted to comparatively examine mediastinal organ innervation and clarify interorgan and neurotissue relationships during early postnatal ontogenesis, when circulation switches from placental to pulmonary and cardiorespiratory regulation is established.
Population
Frontal sections through the cardiopulmonary complex of rats at 1, 7, 10, and 14 days of age
Comparison
Innervation across postnatal developmental stages (1, 7, 10, and 14 days)
Design
Preclinical observational histological study
Authors
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Highlights rat cardiac innervation patterns; leaves open human clinical translation.
This study maps the early postnatal development of cardiac and mediastinal innervation in rats, highlighting a shift from early parasympathetic dominance to widespread nerve fiber growth by day 14.
Ei et al. (2024) studied Early postnatal ontogenesis. Immunohistochemical analysis was evaluated on Morphological features of mediastinum organs innervation. Immunohistochemical analysis in rats aged 1 to 14 days revealed heterochronic development of the terminal synaptic network, with early cholinergic predominance and subsequent active nerve fiber growth.
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