Key result
Sprague-Dawley rat cardio-respiratory systems remain immature at birth with cardiomyocyte hypertrophy continuing until day 30.
Why the study?
To accurately distinguish potential detrimental effects of new drugs on the cardio-respiratory system, it is essential to define normal tissue remodeling during development and maturation in juvenile rats.
Population
51 juvenile Sprague-Dawley rats from birth to postnatal day 30
Design
Histomorphologic and immunohistochemical study
Follow-up
30 days
Authors
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Neonatal rat cardio-respiratory studies require age-specific controls; leaves open optimal modeling windows for translational research.
Vrolyk et al. (2016) studied Normal tissue remodeling features characterizing the development and maturation of the cardio-respiratory system (n=51). Postnatal development was evaluated on Histomorphological postnatal changes of the cardio-respiratory system. The cardio-respiratory system of Sprague-Dawley rats is immature at birth, with lungs and airways reaching maturity 3 weeks after birth and cardiomyocyte hypertrophy continuing until postnatal day 30.
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