Cellular localization of apelin and its receptor in the anterior pituitary: evidence for a direct stimulatory action of apelin on ACTH release

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Population

Adult male rat pituitary gland (ex vivo perifusion system)

Comparison

Apelin 17 (K17F, 10(-6) M) vs Apelin 10 (R10F, 10 M) and basal conditions

Design

Preclinical

Authors

Discussion

No immediate clinical implications from animal data; extends evidence for apelin's pituitary actions but requires human validation.

Population

Adult male rat pituitary gland (ex vivo perifusion system)

Intervention

Apelin 17 (K17F, 10(-6) M)

Comparator

Apelin 10 (R10F, 10(-6) M) (inactive fragment) and basal conditions

Outcome

Basal and K(+)-evoked ACTH releasesurrogate

Apelin acts directly on the anterior pituitary to stimulate ACTH release, indicating a potential autocrine/paracrine role.

Goazigo et al. (2006) studied this question.

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