December 1, 1991Journal of Endocrinology

Atrial Natriuretic Peptide Is a Physiological Inhibitor of Acth Release: Evidence From Immunoneutralization in Vivo

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Why the study?

Does ANP immunoneutralization increase ACTH release in male rats?

Population

Male rats (anaesthetized with sodium pentobarbitone or conscious)

Comparison

Intracerebroventricular infusion or intravenous… vs Control (non-immune) sheep serum

Design

Preclinical

Authors

GFGeorge FinkUniversité Libre de Bruxelles RDR. C. DowMRC Centre for Regenerative Medicine DCDavid CasleyThe Royal Melbourne Hospital

Discussion

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Implication

ANP may inhibit ACTH in male rats; leaves open human relevance and any therapeutic role.

Structured PICO

Does ANP immunoneutralization increase ACTH release in male rats?

Population

Male rats (anaesthetized with sodium pentobarbitone or conscious)

Intervention

Intracerebroventricular infusion (1 microliters/min for 30 min) or intravenous infusion (0.8 ml) of sheep anti-ANP serum

Comparator

Control (non-immune) sheep serum

Outcome

Plasma concentrations of ACTH and corticosteronesurrogate

ANP acts as a physiological inhibitor of ACTH secretion in conscious male rats, suggesting it functions as a hypothalamic neurohormone.

Cite This Study

Fink et al. (1991) studied this question.

synapsesocial.com/papers/6a8aa263a14d41d02f433f6d https://doi.org/10.1677/joe.0.131r009

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Atrial Natriuretic Peptide Is a Physiological Inhibitor of Acth Release: Evidence From Immunoneutralization in Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Atrial Natriuretic Peptide Is a Physiological Inhibitor of Acth Release: Evidence From Immunoneutralization in Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider