December 1, 1992Proceedings of the National Academy of SciencesOpen Access

The role of endogenous atrial natriuretic peptide in resting and stress-induced release of corticotropin, prolactin, growth hormone, and thyroid-stimulating hormone.

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Population

Conscious freely moving male rats

Comparison

Microinjection of highly specific antiserum… vs Microinjection of control normal rabbit serum…

Design

Preclinical

Follow-up

3 hours

Authors

CFCelso Rodrigues FranciUniversidade de Ribeirão Preto JAJ. A. Anselmo‐FranciUniversidade de São Paulo SMSamuel M. McCannThe Wistar Institute

Discussion

Member takes

Implication

ANP modulates pituitary stress hormones in rodents; leaves open any human neuroendocrine role or therapeutic relevance.

Structured PICO

Population

Conscious freely moving male rats

Intervention

Microinjection of highly specific antiserum against atrial natriuretic peptide (AB-ANP) into the third cerebral ventricle

Comparator

Microinjection of control normal rabbit serum (NRS) into the third cerebral ventricle

Outcome

Plasma concentrations of ACTH, prolactin, growth hormone, and thyroid-stimulating hormone under basal conditions and after ether stresssurrogate

Endogenous ANP plays a physiologically significant role in suppressing ACTH release and augmenting prolactin release during stress, and inhibiting resting growth hormone release.

Cite This Study

Franci et al. (1992) studied this question.

synapsesocial.com/papers/6a76eb183da069e66cbd6bfd https://doi.org/10.1073/pnas.89.23.11391

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The role of endogenous atrial natriuretic peptide in resting and stress-induced release of corticotropin, prolactin, growth hormone, and thyroid-stimulating hormone.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The role of endogenous atrial natriuretic peptide in resting and stress-induced release of corticotropin, prolactin, growth hormone, and thyroid-stimulating hormone.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider